Former Liverpool attacker Ryan Babel found the back of the net for Fulham but it was not enough as the Cottagers suffered relegation from the Premier League.
Dutch international winger Babel scored what proved to be the consolation goal for Fulham who were thrashed 4-1 in their London Derby clash with Watford.
The Hornets took the lead midway into the first half through Abdoulaye Doucoure for his second Premier League goal in as many games.
Doucoure had earlier scored the lone goal for Watford in their 2-1 loss to Manchester United at the weekend.
Fulham equalised in the 33rd minute through the aforementioned Babel as both teams went to the break level.
Watford then scored three second-half goals to condemn visitors Fulham to a heavy defeat.
Will Hughes scored a superb goal for the home side on 63 minutes before substitute Andre Gray provided assists for Troy Deeney and Kiko Femenia to make it a convincing win over the Cottagers.
The thumping win for the Hornets ensures that Fulham will play next season in the second tier of English football (English Championship) after just one season in the Premier League.
Fulham has secured promotion to the top flight of English football at the end of the last campaign.